Nod32 is the best. It's subscription based. $90 for 2 years, which entitles you to latest versions of the application, and viruses. I had been trying out kaspersky, norton, mcafee and avg and they were all resource hogs, had annoying installations and other problems, eventually I tryed nod32 and it caught a virus... LOL... none of the others found it, only nod32. I couldn't find a crack for it (unlike the others) which detered me, but when I realized it was subscription based and cheap as hell. I bought it and it's made me the happyest man on earth. The end.
Oh, and Oldskoolie, I got no idea what you're on about nod32 doesn't have annoying popups if you select the option to not annoy you, or even notify you via e-mail. It also automatically updates online without having to do anything. Maybe you used an old version? Or maybe you're crazy and were trying to use Notepad? I'm not sure, what happened, but it has been the best for me.